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Understanding Myofascial Trigger Points: The Clinical Science Behind “Muscle Knots”

Side of Leg Pain

Quick answer: Myofascial trigger points (“muscle knots”) are not permanent structural lumps, but rather microscopic clusters of muscle fibers locked in a continuous contraction—a state driven by excessive acetylcholine release that pinches local capillaries, restricts blood flow, and traps inflammatory chemicals. Confirmed by NIH microdialysis and ultrasound elastography as dark, measurably stiffer nodules with reduced […]

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