Muscle knots in the Biceps Brachii are typically located in the center of the upper arm, between the shoulder and elbow. These muscle knots can refer pain to the front of the shoulder, elbow crease, and even down into the forearm, often mimicking tendonitis or nerve compression. You may feel aching, weakness, or discomfort during lifting, pulling, or rotating the forearm, like turning a doorknob or using a screwdriver.